01. Team Capabilities
The team is led by a former Associate Research Professor at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences (SIMM-CAS), and comprises three PhDs with membrane protein research experience and eight master's degree holders with biopharmaceutical industry experience. Team members are recruited from the Institute of Biophysics (CAS), SIMM-CAS, Tsinghua University, Fudan University, and ShanghaiTech University, combining deep academic rigor with hands-on CRO project experience.
02. Strong Professional Background
The core team members come from pivotal fields—including pharmaceutical R&D, top-tier research institutions, and structural biology—ensuring comprehensive knowledge coverage across the entire value chain, from basic research to applied translation.
- Senior R&D Manager
- Senior R&D Manager
- Senior R&D Manager
- Vector Design and Construction
- Cell Line Development and Protein Expression
- Isolation and Purification of Target Protein
- In vitro functional activity assessment
- Drug formulation process development and product delivery
Core Team Introduction
Chief Scientist
Former Researcher, SIMM, CAS
PhD, Institute of Biophysics, CAS
Long-term focus on structural biology, membrane protein structure-function, Cryo-EM, and X-ray crystallography.
2 Nature papers, 1 Science paper; 10+ high-impact publications in total
Senior Scientist
PhD, ShanghaiTech University
Postdoc, iHuman Institute, Shanghai Tech
Long-term focus on olfactory receptor structure-function; comprehensive experience in membrane protein Cryo-EM analysis.
Built a membrane protein lab platform from scratch as PI; solved 8 olfactory receptor complex structures.
Senior R&D Manager
12 years of biopharmaceutical R&D and team management experience
As core member, contributed to a novel drug candidate (Class 1, NMPA) that has advanced to Phase II clinical trials; 13 patents.
Built 4 recombinant protein expression systems; delivered 100+ membrane protein projects; brings hands-on CRO project delivery experience.
Expertise Showcase
GPCRs are the membrane protein class with the team's most systematic technical accumulation and richest research experience, with long-term work on expression, purification, stability optimization, complex preparation, and Cryo-EM structural studies across GPCR subclasses.
GCGR · GLP-1R · GIPR · FFAR1 · FFAR2 · SSTR family · NMUR2
Experience with GCGR structural studies under different ligand and effector protein states.
mGlu2-4 · mGlu7 · NPY1R · NPY2R · A2AR · NTSR1 · DRD family · 5-HT receptor family
Experience with multiple mGluR subtypes and homo-/heterodimer structural studies, covering different conformations and ligand recognition mechanisms.
CCR5 · CX3CR1 · FPR2 · GPR15 · CMKLR1 · GPR1
Covering difficult structural targets such as CCR5, CX3CR1, and FPR2.
ADGRD1 · ADGRF1 · ADGRG6 · ADGRV1 · T2R14 · T2R46
Covering complex membrane protein systems beyond Class A, including bitter taste receptors.
Covering Class A, adhesion, and bitter taste receptor systems
Endocrine · Neurological · Chemokine · Immunity · Inflammation · Adhesion & Other Complex GPCRs · Metabolic
Expression · Purification · Stabilization · Cryo-EM structural analysis
Representative Research Outputs
The team's membrane protein structural research has been published in journals including Science, Nature, Nature Chemical Biology, Nature Communications, Cell Research, Science Advances, Nature Structural & Molecular Biology, and Protein & Cell.
| Research Area | Representative Targets | Representative Outputs |
|---|---|---|
| Metabolic / Endocrine GPCR | GCGR | Gs / Gi recognition and receptor activation mechanism studies |
| Neurological GPCR | mGlu2 / mGlu4 | Gi binding and receptor structure studies |
| NPY Receptors | Y1R / Y2R | Ligand recognition and receptor activation mechanisms |
| Adhesion GPCR | ADGRD1 / ADGRF1 | Tethered agonism mechanism studies |
| Chemokine Receptors | CCR5 | Ligand recognition and receptor activation mechanisms |
| Chemokine Receptors | CX3CR1 | Cholesterol-regulated receptor activation studies |
| Inflammation-related GPCR | FPR2 | Ligand recognition and neuroprotective mechanism studies |
| Reproductive / Endocrine | SSTR family | Ligand recognition and selectivity mechanism studies |
| Lipid Metabolism | FFAR1 / FFAR2 | Endogenous ligand recognition and activation mechanisms |
| Purinergic Receptors | P2Y1R / P2Y12R | Ligand recognition and signal transduction studies |
| Reproductive Endocrine | NMUR2 | Ligand binding and receptor activation mechanisms |
| Oncology / Immunity | ADGRG6 | Allosteric ligand binding mechanism studies |
| Taste Receptors | T2R14 / T2R46 | Ligand binding mode studies |